abstract：OBJECTIVE:Individual differences in sensitivity to cyclical changes in ovarian steroids estradiol (E2) and progesterone (P4) have been implicated in the pathophysiology of menstrually related mood disorder (MRMD). However, no prospective studies have investigated psychosocial risk factors for sensitivity to hormone eff...

journal_title：Psychoneuroendocrinology

authors： Eisenlohr-Moul TA,Rubinow DR,Schiller CE,Johnson JL,Leserman J,Girdler SS

更新日期：2016-05-01 00:00:00

abstract：:Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise. Here, we examine the lasting effects of adolescent caffeine consumption on anxiety-related behaviors and several neuroendocrine measures in adulthood. Adolescent male Sprague-Dawley rats consumed caffeine ...

journal_title：Psychoneuroendocrinology

authors： O'Neill CE,Newsom RJ,Stafford J,Scott T,Archuleta S,Levis SC,Spencer RL,Campeau S,Bachtell RK

更新日期：2016-05-01 00:00:00

abstract：:Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis influences the risk for developing stress-related disorders. Sex-dependent differences in the HPA axis stress response are believed to contribute to the different prevalence rates of stress-related disorders found in men and women. However, studies examini...

journal_title：Psychoneuroendocrinology

authors： Stephens MA,Mahon PB,McCaul ME,Wand GS

更新日期：2016-04-01 00:00:00

abstract：:This study addressed the question of whether extinction in pairs would have a beneficial effect on extinction of fear conditioning. To that end, we established an experimental setting for extinction in which we trained animals to extinguish contextual fear memory in pairs. Taking advantage of the role of oxytocin (OT)...

journal_title：Psychoneuroendocrinology

authors： Brill-Maoz N,Maroun M

更新日期：2016-04-01 00:00:00

abstract：:Despite the high prevalence of stress exposure healthy adaptation or resilience is a common response. Theoretical work and recent empirical evidence suggest that a robust reward system, in part, supports healthy adaptation by preserving positive emotions even under exceptionally stressful circumstances. We tested this...

journal_title：Psychoneuroendocrinology

authors： Corral-Frías NS,Nadel L,Fellous JM,Jacobs WJ

更新日期：2016-04-01 00:00:00

abstract：:Circulating cortisol levels are known to influence explicit memory in humans and other primates. The present study investigated salivary cortisol and its association with explicit memory performance in 99 postmenopausal women (64 treated with conjugated equine estrogens or estradiol, and 35 matched controls not using ...

journal_title：Psychoneuroendocrinology

authors： Hampson E,Duff-Canning SJ

更新日期：2016-02-01 00:00:00

abstract：:Repeated exposure to homotypic laboratory psychosocial stressors typically instigates rapid habituation in hypothalamic-pituitary-adrenal (HPA) axis-mediated stress responses in humans. However, emerging evidence suggests the combination of physical stress and social evaluative threat may be sufficient to attenuate th...

journal_title：Psychoneuroendocrinology

authors： Boyle NB,Lawton C,Arkbåge K,West SG,Thorell L,Hofman D,Weeks A,Myrissa K,Croden F,Dye L

更新日期：2016-01-01 00:00:00

abstract：:Suicide is a major cause of death worldwide, responsible for 1.5% of all mortality. The causes of suicidal behavior are not fully understood. Dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, is one potential risk factor. This meta-analytic review aimed (i) to estimate th...

journal_title：Psychoneuroendocrinology

authors： O'Connor DB,Ferguson E,Green JA,O'Carroll RE,O'Connor RC

更新日期：2016-01-01 00:00:00

abstract：:In addition to its classical role in mediating responses to pain, the opioid system is strongly implicated in the regulation of social behavior. In young laboratory animals, low doses of opioid analgesic drugs reduce responses to isolation distress and increase play behavior. However, little is known about how opioid ...

journal_title：Psychoneuroendocrinology

authors： Bershad AK,Seiden JA,de Wit H

更新日期：2016-01-01 00:00:00

abstract：:The dominant characterization of the physiological and behavioral human stress reaction is the fight-or-flight response. On the other hand, it has been suggested that social affiliation during stressful times ("tend-and-befriend") also represents a common adaptive response to stress, particularly for women. In the cur...

journal_title：Psychoneuroendocrinology

authors： Berger J,Heinrichs M,von Dawans B,Way BM,Chen FS

更新日期：2016-01-01 00:00:00

abstract：:Sexual dysfunction is not a symptom of PTSD but is a common clinical complaint in trauma survivors with this disorder. In that there are biological parallels in the neuroendocrine processes underlying both PTSD and sexual behavior, we conducted an exploratory investigation of the relationship of PTSD and related neuro...

journal_title：Psychoneuroendocrinology

authors： Lehrner A,Flory JD,Bierer LM,Makotkine I,Marmar CR,Yehuda R

更新日期：2016-01-01 00:00:00

abstract：:In the United States, more than ten million women use contraceptive hormones. Ethinyl estradiol and levonorgestrel have been mainstay contraceptive hormones for the last four decades. Surprisingly, there is scant information regarding their action on the central nervous system and behavior. Intact female rats received...

journal_title：Psychoneuroendocrinology

authors： Simone J,Bogue EA,Bhatti DL,Day LE,Farr NA,Grossman AM,Holmes PV

更新日期：2015-12-01 00:00:00

abstract：:The long-term consequences of exposure to excess stress, particularly during sensitive developmental windows, on the initiation and progression of many complex, common physical and mental disorders that confer a major global burden of disease are well established. The period of intrauterine life represents among the m...

journal_title：Psychoneuroendocrinology

authors： Entringer S,Buss C,Wadhwa PD

更新日期：2015-12-01 00:00:00

abstract：:Aging remains the main risk factor to suffer Alzheimer's disease (AD), though epidemiological studies also support that type 2 diabetes (T2D) is a major contributor. In order to explore the close relationship between both pathologies we have developed an animal model presenting both AD and T2D, by crossing APP/PS1 mic...

journal_title：Psychoneuroendocrinology

authors： Ramos-Rodriguez JJ,Jimenez-Palomares M,Murillo-Carretero MI,Infante-Garcia C,Berrocoso E,Hernandez-Pacho F,Lechuga-Sancho AM,Cozar-Castellano I,Garcia-Alloza M

更新日期：2015-12-01 00:00:00

abstract：:Recent evidence suggests that testosterone is negatively correlated with empathic processes in both men and women. Also, administration of testosterone to young women impairs socio-cognitive performance as assessed using the "Reading the Mind in the Eyes Task", especially among those exposed to elevated testosterone c...

journal_title：Psychoneuroendocrinology

authors： Carré JM,Ortiz TL,Labine B,Moreau BJ,Viding E,Neumann CS,Goldfarb B

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:One proposed mechanism for the association between social isolation and poor health outcomes is inflammation. Lonely or socially disconnected individuals show greater inflammatory responses, including up-regulation of pro-inflammatory gene expression, and people who are sensitive to cues of social disconnect...

journal_title：Psychoneuroendocrinology

authors： Moieni M,Irwin MR,Jevtic I,Breen EC,Cho HJ,Arevalo JM,Ma J,Cole SW,Eisenberger NI

更新日期：2015-12-01 00:00:00

abstract：:Individual differences in the activity of the hypothalamic pituitary adrenal (HPA) axis are often operationalized using summary measures of cortisol that are taken to represent stable individual differences. Here we extend our understanding of a novel latent variable approach to latent trait cortisol (LTC) as a measur...

journal_title：Psychoneuroendocrinology

authors： Giesbrecht GF,Bryce CI,Letourneau N,Granger DA,APrON study Team.

更新日期：2015-12-01 00:00:00

abstract：:Inflammation, which may be present in a subgroup of individuals with major depressive disorder (MDD), activates the kynurenine metabolic pathway to produce kynurenine metabolites kynurenic acid (KynA) and quinolinic acid (QA). We have previously reported an association between the ratio of KynA to QA and hippocampal v...

journal_title：Psychoneuroendocrinology

authors： Savitz J,Dantzer R,Meier TB,Wurfel BE,Victor TA,McIntosh SA,Ford BN,Morris HM,Bodurka J,Teague TK,Drevets WC

更新日期：2015-12-01 00:00:00

abstract：:The cortisol awakening response (CAR) can be assessed from saliva samples collected at home, which confers ecological validity but lacks researcher oversight. Participant non-adherence to requested saliva sampling regimes leads to inaccurate CAR estimates. Moderate sampling delays of just 8 (5-15) min between awakenin...

journal_title：Psychoneuroendocrinology

authors： Smyth N,Thorn L,Hucklebridge F,Evans P,Clow A

更新日期：2015-12-01 00:00:00

abstract：:Binge eating is a behavior observed in a variety of human eating disorders. Ad libitum fed rodents daily and time-limited exposed to a high-fat diet (HFD) display robust binge eating events that gradually escalate over the initial accesses. Intake escalation is proposed to be part of the transition from a controlled t...

journal_title：Psychoneuroendocrinology

authors： Valdivia S,Cornejo MP,Reynaldo M,De Francesco PN,Perello M

更新日期：2015-10-01 00:00:00

abstract：:The association between SES and health is well established; however, only a handful of studies have investigated the relationship between SES and daily cortisol parameters. Further, within this small literature, virtually no studies have looked at psychological factors that might mitigate this relationship. In this st...

journal_title：Psychoneuroendocrinology

authors： Zilioli S,Imami L,Slatcher RB

更新日期：2015-10-01 00:00:00

abstract：:Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency. Prenatal androgen exposure has been suggested to influence mental health, but population based studies on psychiatric morbidity among girls and...

journal_title：Psychoneuroendocrinology

authors： Engberg H,Butwicka A,Nordenström A,Hirschberg AL,Falhammar H,Lichtenstein P,Nordenskjöld A,Frisén L,Landén M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Metabolism of dietary fatty acids (FAs), and its relationship with the hypothalamic-pituitary-adrenal (HPA)-axis, have been found to be altered in major depressive disorder (MDD). Moreover, indications exist that these factors are associated with antidepressant-response. If we better understand these associa...

journal_title：Psychoneuroendocrinology

authors： Mocking RJ,Verburg HF,Westerink AM,Assies J,Vaz FM,Koeter MW,Ruhé HG,Schene AH

更新日期：2015-09-01 00:00:00

abstract：:Patients with long-term remission of Cushing's disease (CD) demonstrate residual psychological complaints. At present, it is not known how previous exposure to hypercortisolism affects psychological functioning in the long-term. Earlier magnetic resonance imaging (MRI) studies demonstrated abnormalities of brain struc...

journal_title：Psychoneuroendocrinology

authors： Bas-Hoogendam JM,Andela CD,van der Werff SJ,Pannekoek JN,van Steenbergen H,Meijer OC,van Buchem MA,Rombouts SA,van der Mast RC,Biermasz NR,van der Wee NJ,Pereira AM

更新日期：2015-09-01 00:00:00

abstract：:Recent evidence suggests that poor sleep is a potential pathway underlying the association between stressful experiences and the diurnal cortisol profile. However, existing findings are largely limited to adults. The present study examines whether poor sleep (duration, quality) mediates the relation between stressful ...

journal_title：Psychoneuroendocrinology

authors： Ly J,McGrath JJ,Gouin JP

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:Long-term opioid therapy has been associated with low cortisol levels due to central suppression of the hypothalamic-pituitary-adrenal axis. The implications of hypocortisolism on wellbeing have not been established. Our aim was to determine whether intervention with physiologic glucocorticoid replacement th...

journal_title：Psychoneuroendocrinology

authors： Nenke MA,Haylock CL,Rankin W,Inder WJ,Gagliardi L,Eldridge C,Rolan P,Torpy DJ

更新日期：2015-06-01 00:00:00

abstract：:Prenatal maternal stress (PNMS) predicts psychosocial development in offspring. It has been hypothesized that during PNMS, glucocorticoids pass the placenta, reaching the foetus, leading to a long-term reprogramming and dysregulation of the foetal hypothalamic-pituitary-adrenal (HPA) axis. However, results are inconsi...

journal_title：Psychoneuroendocrinology

authors： Yong Ping E,Laplante DP,Elgbeili G,Hillerer KM,Brunet A,O'Hara MW,King S

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:A wide variety in hydrocortisone (HC) substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency (SAI). However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. OBJECTIVE:To examine the effects of a high physiological...

journal_title：Psychoneuroendocrinology

authors： Werumeus Buning J,Brummelman P,Koerts J,Dullaart RP,van den Berg G,van der Klauw MM,Tucha O,Wolffenbuttel BH,van Beek AP

更新日期：2015-05-01 00:00:00

abstract：:The cortisol level in fingernails may reflect the hormone's cumulative production over a long period, but the notions have not been fully established. In this study, we investigated the association of cortisol in fingernails with cortisol accumulation over a long period (hair cortisol) and over a relatively short peri...

journal_title：Psychoneuroendocrinology

authors： Izawa S,Miki K,Tsuchiya M,Mitani T,Midorikawa T,Fuchu T,Komatsu T,Togo F

更新日期：2015-04-01 00:00:00

abstract：:Estrogen regulates neuroendocrine and inflammatory processes that play critical roles in neuroinflammation, anxiety, and chronic pain. Patients suffering from chronic pain often complain of anxiety. However, limited information is available regarding the neural circuitry of chronic pain-related anxiety and the related...

journal_title：Psychoneuroendocrinology

authors： Liu SB,Tian Z,Guo YY,Zhang N,Feng B,Zhao MG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Telomere shortening, a biomarker of cellular aging, has been associated with aging-related diseases. While psychological stress has been implicated in the process of telomere shortening, associations with activity of physiological stress systems have remained elusive. We studied whether leukocyte telomere len...

journal_title：Psychoneuroendocrinology

authors： Savolainen K,Eriksson JG,Kajantie E,Lahti J,Räikkönen K

更新日期：2015-03-01 00:00:00

abstract：:The ability to predict the behavior of others based on their mental states is crucial for social functioning. Previous studies have provided evidence for the role of Oxytocin (OXT) in enhancing the ability to mentalize. It has also been demonstrated that the effect of OXT seems to strongly depend on socio-cognitive sk...

journal_title：Psychoneuroendocrinology

authors： Feeser M,Fan Y,Weigand A,Hahn A,Gärtner M,Böker H,Grimm S,Bajbouj M

更新日期：2015-03-01 00:00:00

abstract：:Anticipation may play a role in shaping biological reactions to repeated stressors-a common feature of modern life. We aimed to demonstrate that: (a) individuals who display a larger cortisol response to an initial stressor exhibit progressive anticipatory sensitization, showing progressively higher cortisol levels be...

journal_title：Psychoneuroendocrinology

authors： Turan B,Foltz C,Cavanagh JF,Wallace BA,Cullen M,Rosenberg EL,Jennings PA,Ekman P,Kemeny ME

更新日期：2015-02-01 00:00:00

abstract：:Allopregnanolone (AP) is an endogenous neurosteroid. It modulates the effect of γ-amino-butyric acid (GABA) on the GABA type A (GABAA) receptor, which leads to increased receptor activity. Since the GABA-system is mainly inhibitory, increased AP activity leads to modulation of neuronal activity. In vitro studies of GA...

journal_title：Psychoneuroendocrinology

authors： Bengtsson SK,Nyberg S,Hedström H,Zingmark E,Jonsson B,Bäckström T,Bixo M

更新日期：2015-02-01 00:00:00

abstract：:Ghrelin is a 28-amino-acid peptide hormone, first described in 1999 and broadly expressed in the organism. As the only known orexigenic hormone secreted in the periphery, it increases hunger and appetite, promoting food intake. Ghrelin has also been shown to be involved in various physiological processes being regulat...

journal_title：Psychoneuroendocrinology

authors： Wittekind DA,Kluge M

更新日期：2015-02-01 00:00:00

abstract：:Pre-clinical and clinical evidence indicates that opioid drugs have stress-dampening effects. In animal models, opioid analgesics attenuate responses to isolation distress, and in humans, opioids reduce stress related to anticipation of physical pain. The stress-reducing effects of opioid drugs may contribute to their...

journal_title：Psychoneuroendocrinology

authors： Bershad AK,Jaffe JH,Childs E,de Wit H

更新日期：2015-02-01 00:00:00

abstract：:Environmental enrichment (EE) mimics positive life experiences by providing enhanced social and physical stimulation. Placement into EE following weaning, or in later life, confers beneficial outcomes on both emotional and cognitive processes. However, anxiety-like behavior is also reported, particularly in rats expos...

journal_title：Psychoneuroendocrinology

authors： Connors EJ,Migliore MM,Pillsbury SL,Shaik AN,Kentner AC

更新日期：2015-02-01 00:00:00

abstract：:Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state. We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP...

journal_title：Psychoneuroendocrinology

authors： Balázsfi D,Pintér O,Klausz B,Kovács KB,Fodor A,Török B,Engelmann M,Zelena D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their assoc...

journal_title：Psychoneuroendocrinology

authors： Black CN,Bot M,Scheffer PG,Cuijpers P,Penninx BW

更新日期：2015-01-01 00:00:00

abstract：:Sex differences in behavior are widespread and often caused by hormonal differences between the sexes. In addition to hormones, the composition and numbers of the sex chromosomes also affect a variety of sex differences. In humans, X-chromosome genes are implicated in neurobehavioral disorders (i.e. fragile-X, autism)...

journal_title：Psychoneuroendocrinology

authors： Cox KH,Quinnies KM,Eschendroeder A,Didrick PM,Eugster EA,Rissman EF

更新日期：2015-01-01 00:00:00